Docenti

Stefano Merigliano

Stefano Merigliano

Full Professor

Telefono: 049 8216426

Phone lab: 049 8212060

E-mail: stefano.merigliano@unipd.it

Group Website:

http://www.centroesofagopadova.org

http://www.colon.it

Education
1976 : Medicine Doctor, University of Padova
1981: Residency in General Surgery, University of Padova

Positions
1981 – 1984 : Assistant Professor of  Surgery –University of Padova School of Medicine
1984 : Associate Professor of  Surgery - University of Padova School of Medicine
1996 – 1998 : Member of the Scientific Committee, University of Padova Center for Information Technology
1990 – 1993 : Chief of University of Padova Center for Information Technology
1987 –  to present : Chief of the Interdepartmental Center for Experimental Surgery of the University of Padova
2012 – to present: Chief of the 3rd Clinical Surgery of the University of Padova
1988 - 1992 : University Lecturer on Experimental Surgery and Microsurgery
1992 - 1996 : University Lecturer on Semeiotic and Surgical Methodology
1996 - present : Chair of General Surgery
2007:  Full Professor of Surgery - University of Padova School of Medicine
2008 - 2011:  Prorector for Information Technology, University of Padova
2015 - present: Chairman of the Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova

Specific interests and activity can be identified in the following fields:

- Experimental surgery and microsurgery with applications in the clinical field;
- Pathophysiology of the esophagus, both in motility disorders, gastro-oesophageal reflux disease and esophageal cancer treatment;
- Applications of information technology to medicine for both diagnostic and educational purposes.

A) Experimental Surgery and Microsurgery.

It is one of his privileged fields of research, taken care of throughout the career, also because it is closely linked to his didactic role. The researches were mainly directed towards clinical applications of microsurgery (treatment of esophageal carcinoma in the cervical portion, varicocele therapy). Particular importance was also given to the didactic aspect with the publication of a “Manual of Experimental Surgery and Microsurgery” for medicine students and General Surgery residents.

B) Esophageal disorders.

Researches related to information technology applied to the study of ph-metry and continue gastro-esophageal manometry. Prof. Merigliano development an innovative microprocessor-based instrument recognized at international level.

He dedicated also to esophageal cancer treatments and in recent years to mininvasive surgery for esophageal disorders.

C) Application of information technology in medicine.

Prof. Merigliano coordinated a research group (with a research contract among University of Padova and IBM) dealing with the application on information technology and computer simulation in medical education. This project grown into a national project involving IBM and 12 Italian Univeristies.

These researches were preliminary to the introduction, in the context of the activation of the new table XVIII medical curriculum, of the Surgical Semeiotics and Clinical Methodology teaching.

From 1997 to 2000 he was general coordinator of the National Telemedicine Plan - Theme IV - financed by the MURST with 10.5 billion of Lire.

Since 2000 he has been coordinator of the first project funded by the European Space Agency for distance training of doctors and since 2003 for the distance training of nurses in Romania and Bulgaria via satellite. Both projects are under the patronage of the Veneto Region.

D) Mininvasive colo-rectal surgery.

In January 2001 Prof. Merigliano established as Director the Unit of Colo-Proctology Surgery at the S. Antonio Hospital, dedicated to the research and development of colorectal laparoscopic surgery. In 2002 and 2003, there were 24 residential courses of laparoscopic colo-rectal surgery for national surgeons, and the production of 3 multimedia courses on CD-ROM.

Publications:  more than 220 international papers, 5 monographies and more than 100 abstracts.

Last 5 year publications:

1: Valmasoni M, Pierobon ES, Zanchettin G, Briscolini D, Moletta L, Ruol A, Salvador R, Merigliano S. Cervical Esophageal Cancer Treatment Strategies: A Cohort Study Appraising the Debated Role of Surgery. Ann Surg Oncol. 2018 Jul 9. doi: 10.1245/s10434-018-6648-6. [Epub ahead of print] PubMed PMID: 29987601.

2: Bressan A, Marini L, Michelotto M, Frigo AC, Da Dalt G, Merigliano S, Polese L. Risk factors including the presence of inflammation at the resection margins for colorectal anastomotic stenosis following surgery for diverticular disease. Colorectal Dis. 2018 Apr 28. doi: 10.1111/codi.14240. [Epub ahead of print] PubMed PMID: 29706003.

3: Polese L, Bressan A, Savarino E, Vecchiato M, Turoldo A, Frigo A, Sturniolo GC, De Manzini N, Petri R, Merigliano S. Quality of life after laparoscopic sigmoid resection for uncomplicated diverticular disease. Int J Colorectal Dis. 2018 May;33(5):513-523. doi: 10.1007/s00384-018-3005-y. Epub 2018 Mar 10. PubMed PMID: 29525902.

4: Feltracco P, Bortolato A, Barbieri S, Michieletto E, Serra E, Ruol A, Merigliano S, Ori C. Perioperative benefit and outcome of thoracic epidural in esophageal surgery: a clinical review. Dis Esophagus. 2018 May 1;31(5). doi: 10.1093/dote/dox135. PubMed PMID: 29211841.

5: Salvador R, Voltarel G, Savarino E, Capovilla G, Pesenti E, Perazzolo A, Nicoletti L, Costantini A, Merigliano S, Costantini M. The natural history of achalasia: Evidence of a continuum-"The evolutive pattern theory". Dig Liver Dis. 2018 Apr;50(4):342-347. doi: 10.1016/j.dld.2017.11.012. Epub 2017 Nov 26. PubMed PMID: 29208549.

6: Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed PMID: 29167426; PubMed Central PMCID: PMC5700099.

7: Todros S, Pachera P, Baldan N, Pavan PG, Pianigiani S, Merigliano S, Natali AN. Computational modeling of abdominal hernia laparoscopic repair with a surgical mesh. Int J Comput Assist Radiol Surg. 2018 Jan;13(1):73-81. doi: 10.1007/s11548-017-1681-7. Epub 2017 Nov 3. PubMed PMID: 29101640.

8: Frigo A, Costantini M, Fontanella CG, Salvador R, Merigliano S, Carniel EL, Frigo A, Costantini M, Fontanella CG, Salvador R, Merigliano S, Carniel EL, Costantini M, Carniel EL, Frigo A, Merigliano S, Fontanella CG, Salvador R. A Procedure for the Automatic Analysis of High-Resolution Manometry Data to Support the Clinical Diagnosis of Esophageal Motility Disorders. IEEE Trans Biomed Eng. 2018 Jul;65(7):1476-1485. doi: 10.1109/TBME.2017.2758441. Epub 2017 Oct 2. PubMed PMID: 28976308.

9: Polese L, Marini L, Rizzato R, Picardi E, Merigliano S. Endoscopic diode laser therapy for chronic radiation proctitis. Lasers Med Sci. 2018 Jan;33(1):35-39. doi: 10.1007/s10103-017-2323-6. Epub 2017 Sep 11. PubMed PMID: 28895000.

10: Capovilla G, Salvador R, Spadotto L, Voltarel G, Pesenti E, Perazzolo A, Nicoletti L, Merigliano S, Costantini M. Long-term wireless pH monitoring of the distal esophagus: prolonging the test beyond 48 hours is unnecessary and may be misleading. Dis Esophagus. 2017 Oct 1;30(10):1-8. doi: 10.1093/dote/dox069. PubMed PMID: 28859392.

11: Miranda H, Colangelo AC, Antunes M, Schiavone M, Merigliano S, Pizzol D. Giant elephantiasis and inguino-scrotal hernia. PLoS Negl Trop Dis. 2017 Jun 15;11(6):e0005494. doi: 10.1371/journal.pntd.0005494. eCollection 2017 Jun. PubMed PMID: 28617809; PubMed Central PMCID: PMC5472255.

12: Salvador R, Costantini M, Capovilla G, Polese L, Merigliano S. Esophageal Penetration of the Magnetic Sphincter Augmentation Device: History Repeats Itself. J Laparoendosc Adv Surg Tech A. 2017 Aug;27(8):834-838. doi: 10.1089/lap.2017.0182. Epub 2017 Jun 6. PubMed PMID: 28586287.

13: Serafini S, Da Dalt G, Pozza G, Blandamura S, Valmasoni M, Merigliano S, Sperti C. Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature. World J Surg Oncol. 2017 May 2;15(1):93. doi: 10.1186/s12957-017-1157-9. Review. PubMed PMID: 28464920.

14: Salvador R, Savarino E, Pesenti E, Spadotto L, Voltarel G, Capovilla G, Cavallin F, Nicoletti L, Valmasoni M, Ruol A, Merigliano S, Costantini M. Effects of laparoscopic myotomy on the esophageal motility pattern of esophageal achalasia as measured by high-resolution manometry. Surg Endosc. 2017 Sep;31(9):3510-3518. doi: 10.1007/s00464-016-5377-9. Epub 2016 Dec 30. PubMed PMID: 28039638.

15: Zane M, Parello C, Pennelli G, Townsend DM, Merigliano S, Boscaro M, Toniato A, Baggio G, Pelizzo MR, Rubello D, Boschin IM. Estrogen and thyroid cancer is a stem affair: A preliminary study. Biomed Pharmacother. 2017 Jan;85:399-411. doi: 10.1016/j.biopha.2016.11.043. Epub 2016 Nov 26. PubMed PMID: 27899250; PubMed Central PMCID: PMC5218826.

16: Valmasoni M, Pierobon ES, De Pasqual CA, Zanchettin G, Moletta L, Salvador R, Costantini M, Ruol A, Merigliano S. Esophageal Cancer Surgery for Patients with Concomitant Liver Cirrhosis: A Single-Center Matched-Cohort Study. Ann Surg Oncol. 2017 Mar;24(3):763-769. doi: 10.1245/s10434-016-5610-8. Epub 2016 Oct 4. PubMed PMID: 27704371.

17: Salvador R, Spadotto L, Capovilla G, Voltarel G, Pesenti E, Longo C, Cavallin F, Nicoletti L, Ruol A, Valmasoni M, Merigliano S, Costantini M. Mucosal Perforation During Laparoscopic Heller Myotomy Has No Influence on Final Treatment Outcome. J Gastrointest Surg. 2016 Dec;20(12):1923-1930. Epub 2016 Sep 29. PubMed PMID: 27688213.

18: Carniel EL, Frigo A, Costantini M, Giuliani T, Nicoletti L, Merigliano S, Natali AN. A physiological model for the investigation of esophageal motility in healthy and pathologic conditions. Proc Inst Mech Eng H. 2016 Jul 15. pii: 0954411916658915. [Epub ahead of print] PubMed PMID: 27422826.

19: Salvador R, Pesenti E, Gobbi L, Capovilla G, Spadotto L, Voltarel G, Cavallin F, Nicoletti L, Valmasoni M, Ruol A, Merigliano S, Costantini M. Postoperative Gastroesophageal Reflux After Laparoscopic Heller-Dor for Achalasia: True Incidence with an Objective Evaluation. J Gastrointest Surg. 2017 Jan;21(1):17-22. doi: 10.1007/s11605-016-3188-x. Epub 2016 Jun 30. PubMed PMID: 27364725.

20: Pigna E, Berardi E, Aulino P, Rizzuto E, Zampieri S, Carraro U, Kern H, Merigliano S, Gruppo M, Mericskay M, Li Z, Rocchi M, Barone R, Macaluso F, Di Felice V, Adamo S, Coletti D, Moresi V. Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer. Sci Rep. 2016 May 31;6:26991. doi: 10.1038/srep26991. PubMed PMID: 27244599; PubMed Central PMCID: PMC4886631.

21: Valmasoni M, Pierobon ES, Ruol A, De Pasqual CA, Zanchettin G, Moletta L, Salvador R, Costantini M, Merigliano S. Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients. PLoS One. 2016 Apr 18;11(4):e0153068. doi: 10.1371/journal.pone.0153068. eCollection 2016. PubMed PMID: 27088503; PubMed Central PMCID: PMC4835067.

22: Canton SA, Merigliano S, Pasquali C. Prosthetic mesh "slim-cigarette like" for laparoscopic repair of ventral hernias: a new technique without transabdominal fixation sutures. Updates Surg. 2016 Jun;68(2):199-203. doi: 10.1007/s13304-016-0348-1. Epub 2016 Mar 7. PubMed PMID: 26951523.

23: Polese L, Porzionato A, Luisetto R, Mastrogiacomo D, Macchi V, De Caro R, Norberto L, Merigliano S. Roux-en-Y gastrojejunal bypass using a hybrid NOTES-12 mm trocar technique in a porcine model. Minim Invasive Ther Allied Technol. 2016;25(2):86-90. doi: 10.3109/13645706.2015.1125929. Epub 2016 Jan 11. PubMed PMID: 26751102.

24: Sperti C, Moletta L, Merigliano S. Multimodality treatment of recurrent pancreatic cancer: Mith or reality? World J Gastrointest Oncol. 2015 Dec 15;7(12):375-82. doi:  10.4251/wjgo.v7.i12.375. PubMed PMID: 26689800; PubMed Central PMCID: PMC4678384.

25: Beltrame V, Gruppo M, Pedrazzoli S, Merigliano S, Pastorelli D, Sperti C. Mesenteric-Portal Vein Resection during Pancreatectomy for Pancreatic Cancer. Gastroenterol Res Pract. 2015;2015:659730. doi: 10.1155/2015/659730. Epub 2015 Nov 1. PubMed PMID: 26609307; PubMed Central PMCID: PMC4644545.

26: Salvador R, Savarino E, Pesenti E, Spadotto L, Capovilla G, Cavallin F, Galeazzi F, Nicoletti L, Merigliano S, Costantini M. The Impact of Heller Myotomy on Integrated Relaxation Pressure in Esophageal Achalasia. J Gastrointest Surg. 2016 Jan;20(1):125-31; discussion 131. doi: 10.1007/s11605-015-3006-x. Epub 2015 Oct 30. PubMed PMID: 26519153.

27: Valli V, Blandamura S, Pastorelli D, Merigliano S, Sperti C. Nesidioblastosis coexisting with non-functioning islet cell tumour in an adult. Endokrynol Pol. 2015;66(4):356-60. doi: 10.5603/EP.2015.0045. PubMed PMID: 26323473.

28: Beltrame V, Gruppo M, Pastorelli D, Pedrazzoli S, Merigliano S, Sperti C. Outcome of pancreaticoduodenectomy in octogenarians: Single institution's experience and review of the literature. J Visc Surg. 2015 Nov;152(5):279-84. doi: 10.1016/j.jviscsurg.2015.06.004. Epub 2015 Jun 24. Review. PubMed PMID: 26117303.

29: Sperti C, Merigliano S, Moletta L. Metastatic pancreatic tumors: what is the optimal treatment? Minerva Chir. 2015 Apr;70(2):131-9. Epub 2015 Feb 3. Review. PubMed PMID: 25645113.

30: Porzionato A, Polese L, Lezoche E, Macchi V, Lezoche G, Da Dalt G, Stecco C, Norberto L, Merigliano S, De Caro R. On the suitability of Thiel cadavers for natural orifice transluminal endoscopic surgery (NOTES): surgical training, feasibility studies, and anatomical education. Surg Endosc. 2015 Mar;29(3):737-46. doi: 10.1007/s00464-014-3734-0. Epub 2014 Jul 25. PubMed PMID: 25060684.

31: Polese L, Lezoche E, Porzionato A, Lezoche G, Da Dalt G, Macchi V, Stecco C, De Caro R, Norberto L, Merigliano S. Transanal ileoproctostomy is feasible in human cadavers. Colorectal Dis. 2014 Oct;16(10):O367-9. doi: 10.1111/codi.12684. PubMed PMID: 24916474.

32: Beltrame V, Gruppo M, Pastorelli D, Pizzi S, Merigliano S, Sperti C. Extra-gastrointestinal stromal tumor of the pancreas: case report and review of the literature. World J Surg Oncol. 2014 Apr 23;12:105. doi: 10.1186/1477-7819-12-105. Review. PubMed PMID: 24755359; PubMed Central PMCID: PMC4000617.