Surgery of esophagogastric cancer

Esophageal cancer is the seventh most common cancer worldwide accounting for over 570,000 new cases in 2018 and ranks sixth in overall cancer-related mortality with over half million deaths.

Gastric carcinoma is the fourth most common malignancy worldwide and remains the second cause of death of all malignancies worldwide.

Outcome still is dismal despite diagnostic and treatment improvements, with a 5-year survival rate of only 10-30 %. Various multimodality therapies are available, but to date, surgery still remains the best curative approach.

Our group have a thirty-year experience in treating esophagogastric cancer with research interests in multimodality treatments, surgical treatments and techniques and, in recent years, in minimally invasive surgery and translational research.

Research topics

Multimodal treatment of esophagogastric cancer.

Staging and treatment of early esophageal cancer.
Minimally invasive surgery.
Mobile Health applied to cancer survivors.

Cancer cachexia.

Esophageal cancer patient derived organoids.


Valmasoni M, Capovilla G, Pierobon ES, Moletta L, Provenzano L, Costantini M, Salvador R, Merigliano S. A Technical Modification to the Circular Stapling Anastomosis Technique During Minimally Invasive Ivor Lewis Procedure. J Laparoendosc Adv Surg Tech A. 2019 Dec;29(12):1585-1591.

Valmasoni M, Pierobon ES, Capovilla G, Piangerelli A, Moletta L, Costantini M, Salvador R, Merigliano S. Providing surgery for cancer during the COVID-19 pandemic: experience of a northern Italian referral centre. Br J Surg. 2020 Aug;107(9):e326-e327.

Valmasoni M, Pierobon ES, Ruol A, De Pasqual CA, Zanchettin G, Moletta L, Salvador R, Costantini M, Merigliano S. Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients. PLoS One. 2016 Apr 18;11(4):e0153068.

Ruzzo A, Graziano F, Bagaloni I, Di Bartolomeo M, Prisciandaro M, Aprile G, Ongaro E, Vincenzi B, Perrone G, Santini D, Fornaro L, Vivaldi C, Tomasello G, Loupakis F, Lonardi S, Fassan M, Valmasoni M, Sarti D, Lorenzini P, Catalano V, Bisonni R, Del Prete M, Collina G, Magnani M. Glycolytic competence in gastric adenocarcinomas negatively impacts survival outcomes of patients treated with salvage paclitaxel-ramucirumab. Gastric Cancer. 2020 Nov;23(6):1064-1074.

Valmasoni M, Pierobon ES, De Pasqual CA, Zanchettin G, Moletta L, Salvador R, Costantini M, Ruol A, Merigliano S. Esophageal Cancer Surgery for Patients with Concomitant Liver Cirrhosis: A Single-Center Matched-Cohort Study. Ann Surg Oncol. 2017 Mar;24(3):763-769.

Valmasoni M, Pierobon ES, Zanchettin G, Briscolini D, Moletta L, Ruol A, Salvador R, Merigliano S. Cervical Esophageal Cancer Treatment Strategies: A Cohort Study Appraising the Debated Role of Surgery. Ann Surg Oncol. 2018 Sep;25(9):2747-2755.

De Pascale S, Parise P, Valmasoni M, Weindelmayer J, Terraneo F, Cella CA, Giacopuzzi S, Cossu A, Massaron S, Elmore U, Merigliano S, Fumagalli Romario U, On Behalf Of The Italian Society For The Study Of Esophageal Diseases Sisme. Does Pathological Stage and Nodal Involvement Influence Long Term Oncological Outcomes after CROSS Regimen for Adenocarcinoma of the Esophagogastric Junction? A Multicenter Retrospective Analysis. Cancers (Basel). 2021 Feb 7;13(4):666.

People involved

Stefano Merigliano (Full Professor of Surgery)
Michele Valmasoni (Associate Professor of Surgery)

Group members

Giovanni Capovilla, Mario Costantini, Lucia Moletta, Elisa Sefora Pierobon, Luca Provenzano, Renato Salvador, Gianpietro Zanchettin.