Research

Endocrine Diseases

Parathyroid:
A) A retrospective study on primary hyperparathyroidism (pHPT) and renal function comparing patients undergoing selective parathyroidectomy and follow-up patients with or without calcium-mimetic medical therapy.

Thyroid:
A) Radiofrequency ablation (RFA) of thyroid nodules: clinical evaluation of 58 patients underwent RFA for thyroid nodules between 2011 and 2015 in the Unit of Interventistic Radiology of Istituto Oncologico Veneto (IOV) in view to analyse this technique proposed as an alternative to surgery for the treatment of nodular pathology of the thyroid.
B) Risk of malignancy in thyroid nodules classified as TIR3A: a monoinstitutional study to assess the clinical applicability of the TIR3A category in managing thyroid nodules and to examine the malignancy rates of TIR3A in our experience.
C) Evaluation of the follow up of 987 patients underwent thyroidectomy for Papillary Thyroid Carcinoma (PTC) between 2007 to 2015 on the basis of biochemical and morphological variables as serum Tyroglobulin (TG), serum AntiTG-Antibodies,  hrUS.

Adrenal gland:

A) A study on the effects of “ketoconazole” and “metyrapone” on mild subclinical Cushing’s Syndrome reporting our experience.
B) A European multicentric study on surgical traetment of Subclinical Cortisol-Secreting Adrenal Incidentaloma (SCSAI):  the aim  is to evaluate the consequences of surgical removal of SCSAI on hypertension and cardiovascular risk factors in order to investigate the role of surgical excision of SCSAI vs an intensive medical regimen in patients affected by hypertension.

5 Publications

The role of BRAF(V600E) mutation as poor prognostic factor for the outcome of patients with intrathyroid papillary thyroid carcinoma. Pelizzo MR, Dobrinja C, Casal Ide E, Zane M, Lora O, Toniato A, Mian C, Barollo S, Izuzquiza M, Guerrini J, De Manzini N, Merante Boschin I, Rubello D. Biomed Pharmacother. 2014 May;68(4):413-7

Boschin IM, Torresan F, Toniato A, Zane M, Ide EC, Pennelli G, Rampin L, Colletti PM, Rubello D, Pelizzo MR. Incidental medullary thyroid microcarcinoma revealed by mild increase of preoperative serum calcitonin levels: therapeutic implications. Endocrine. 2014 Apr;45(3):448-53.

Pelizzo MR, Torresan F, Boschin IM, Nacamulli D, Pennelli G, Barollo S, Rubello D, Mian C. Early, Prophylactic Thyroidectomy in Hereditary Medullary Thyroid Carcinoma: A 26-year Monoinstitutional Experience. Am J Clin Oncol. 2015 Oct;38(5):508-13. 

Pelizzo MR1, Conti C, Pennelli G, Bellan E, Cook GJ, Wong KK, Colletti PM,Merante Boschin I, Rubello D. Thyroid Paraganglioma: Our Experience and S ystematic Review of the Literature on a Rare Tumor.Am J Clin Oncol. 2016 May 9th.

Marchiori E, Pelizzo MR, Herten M, Townsend DM, Rubello D, Boschin IM. Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene. Biomed Pharmacother. 2017 Aug;92:843-848. Doi: 10.1016/j.biopha.2017.05.028.

Funding

2013: code: 60A07-3821/13   title: "Papillary thyroid carcinoma: gender disparity”.
2014: code: 60A07-0920/14   title: "GPR30: a novel estrogen receptor involved in thyroid tumors?”
2018: code: DOR1884018/18  title "Renal function in primary hyperparathyroidism: prospective comparator study between patients undergoing selective parathyroidectomy and follow-up patients with or without calcium-mimetic medical therapy”

People Involved:

Isabella Merante Boschin, MD, Associated Professor
Carla Scaroni , MD, Associated Professor
Caterina Mian, MD, PhD, Associated Professor
Filippo Ceccato, MD, PhD
Maurizio Iacobone, MD, Associated Professor
Ambrogio Fassina, MD, Associated Professor
Gianmaria Pennelli, MD, PhD

Group Members:

Valentina Camozzi, MD
Chiara Sabbadin, MD
Camillo Aliberti (IOV), MD
Mattia Barbot, MD, resident
Laura Lizzul, MD, resident
Elisa Selmin, MD, resident
Silvia Pinelli, MD, resident
Jacopo Manso, MD, resident
Giulio Franceschet, MD, resident