Research

Microbiota in Health and Disease

The microbiota is relevant to many diseases due to its direct impact on the development and maintenance of the immune system. Moreover, both the microbiota and the immune system are intimately related to many other physiological processes such as metabolism and behaviour, as well as the digestive system. We are focusing our attention on the role of dysbiosis in the pathogenesis of several disorders: inflammatory bowel diseases (Crohn’s disease, Ulcerative colitis), coeliac disease, irritable bowel syndrome, eosinophilic esophagitis and cancer (Barrett’s esophagus and other solid cancers) and non-alcoholic steatohepatitis (NASH). Moreover, we are studying the impact of gut microbiota in the development of surgery complications like post-operative recurrence of Crohn’s disease, pouchitis or cancer recurrence.

Publications:

  1. Furnari M, Savarino E, Bruzzone L, Moscatelli A, Gemignani L, Giannini EG, Zentilin P, Dulbecco P, Savarino V.  Reassessment of the role of methane production between irritable bowel syndrome and functional constipation.J Gastrointestin Liver Dis. 2012 Jun;21(2):157-63.
  2. Scarpa M, Grillo A, Faggian D, Ruffolo C, Bonello E, D'Incà R, Scarpa M, Castagliuolo I, Angriman I. Relationship between mucosa-associated microbiota and inflammatory parameters in the ileal pouch after restorative proctocolectomy for ulcerative colitis.Surgery. 2011 Jul;150(1):56-67
  3. Facchin S, Buda A, Perini B, Sturniolo GC, D'Incà R, Lorenzon G, Savarino R. Microbiota Profile and Dysbiosis Assessment in Clinical Practice: A Pilot Study on IBD Patient. Digestive and Liver Disease, Vol. 50, Issue 2, 2018
  4. Facchin S, Buda A, D'Incà R, Savarino E. Microbiota Profile and Dysbiosis Assessment in Clinical Practice: A Pilot Study on IBD Patients.  May 2018 Gastroenterology 154(6)
  5. Michielan A, D'Incà R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015;2015:628157

Funding 

2009 - Title of The Research Project “Evaluation Of Small Bowel Distension After Ingestion of Oral Lactulose By Means Of Magnetic Resonance Imaging In Healthy Volunteers And A Group Of Patients With Irritable Bowel Syndrome” Funded by Italian Society of Gastroenterology (SIGE)

2016 - Title of The Research Project “Modulazione del microbiota intestinale e infiammazione nelle malattie infiammatorie croniche intestinali” Funded by SILA Srl

People involved:

Edoardo V. Savarino, Associate Professors
Fabiana Zingone, Assistant Professor
Fabio Farinati. Full Professor
Francesco Paolo Russo, Associate Professor
Imerio Angriman, Adjunct Professor
Romeo Bardini, Associate Professor

Groupmembers:

Renata D’Incà, Anna D’Odorico, Francesca Galeazzi (Consultant Gastroenterologists), Marco Scarpa (Consultant Surgeon), Marco della Coletta, Matteo Ghisa, Brigida Barberio and Costanza Orlandi, Roberta Caccaro (Gastroenterology Fellows), Gemma Maddalo (Gastroenterology Fellow, PhD Students), Sonia Facchin, Carla Marinelli, Marco Inferrera and Matteo Martinato (Research Fellows), Greta Lorenzon and Alessandra Rigo (Research Nurses).