Gastric cancer (GC) represents the fifth most common malignancy and the fourth leading cause of cancer-related mortality worldwide. Although the incidence and mor- tality associated with GC has decreased over the last decade, more than 1 million cases were diagnosed in 2020 with an increased incidence among young adults. Multimodal therapy, utilizing a combination of surgery and chemotherapy, represents the best curative-intent option for most patients with localized disease. Nevertheless, disease recurrence is common and represents the leading cause o death in GC patients. In fact, recurrence after curative- intent GC surgery has been reported among more than 50% of patients. Our research mostly focuses on:

- non-clinical and clinical predictors of recurrence
- molecular and clinical determinants of peritoneal dissemination of GC
- molecular biomarkers evaluation in gastric/gastroesophageal junction adenocarcinoma
- predictors of metastatic lymph nodes at preoperative staging
- dynamic prediction of survival with sophisticated statistical approaches (i.e. landmark analyses)

Publications:

Spolverato G, Capelli G, Mari V, Lorenzoni G, Gregori D, Poultsides G, Fields RC, Weber SM, Votanopoulos K, Cho CS, He J, Maithel SK, Pucciarelli S, Pawlik TM. Very Early Recurrence After Curative-Intent Surgery for Gastric Adenocarcinoma. Ann Surg Oncol. 2022 Aug 26. doi: 10.1245/s10434-022-12434-y. Epub ahead of print. PMID: 36018525.

Crimì F, Bao QR, Mari V, Zanon C, Cabrelle G, Spolverato G, Pucciarelli S, Quaia E. Predictors of Metastatic Lymph Nodes at Preoperative Staging CT in Gastric Adenocarcinoma. Tomography. 2022 Apr 22;8(3):1196-1207. doi: 10.3390/tomography8030098. PMID: 35645384; PMCID: PMC9149869.

Spolverato G, Paro A, Capelli G, Dalmacy D, Poultsides GA, Fields RC, Weber SM, Votanopoulos KI, He J, Maithel SK, Pucciarelli S, Pawlik TM. Surgical treatment of gastric adenocarcinoma: Are we achieving textbook oncologic outcomes for our patients? J Surg Oncol. 2022 Mar;125(4):621-630. doi: 10.1002/jso.26778. Epub 2021 Dec 29. PMID: 34964983.

Spolverato G, Azzolina D, Paro A, Lorenzoni G, Gregori D, Poultsides G, Fields RC, Weber SM, Votanopoulos K, Maithel SK, Pucciarelli S, Pawlik TM. Dynamic Prediction of Survival after Curative Resection of Gastric Adenocarcinoma: A landmarking-based analysis. Eur J Surg Oncol. 2022 May;48(5):1025-1032. doi: 10.1016/j.ejso.2021.11.127. Epub 2021 Dec 6. PMID: 34895773.

Spolverato G, Azzolina D, Paro A, Lorenzoni G, Gregori D, Poultsides G, Fields RC, Weber SM, Votanopoulos K, Maithel SK, Pucciarelli S, Pawlik TM. Dynamic Prediction of Survival after Curative Resection of Gastric Adenocarcinoma: A landmarking-based analysis. Eur J Surg Oncol. 2022 May;48(5):1025-1032. doi: 10.1016/j.ejso.2021.11.127. Epub 2021 Dec 6. PMID: 34895773.

Tonello AS, Capelli G, Bao QR, Marchet A, Farinati F, Pawlik TM, Gregori D, Pucciarelli S, Spolverato G. A nomogram to predict overall survival and disease-free survival after curative-intent gastrectomy for gastric cancer. Updates Surg. 2021 Oct;73(5):1879-1890. doi: 10.1007/s13304-021-01083-7. Epub 2021 Jun 14. PMID: 34125428; PMCID: PMC8500903.

People involved:

Prof. Pucciarelli Salvatore, MD (Full Professor)
Prof.ssa Gaya Spolverato, MD (Associate Professor)

Group Member

Scarpa Marco, MD (Faculty)
Maretto Isacco, MD (Faculty)
Perin Alessandro, MD (Faculty)
Ruffolo Cesare, MD(Faculty)
Bao Q. Riccardo (Assegnista di Ricerca)