Research

Regenerative Medicine

Regenerative medicine is a game-changing area of medicine with the potential to fully heal damaged tissues and organs, offering solutions and hope for people who have conditions that today are beyond repair.

Our group is studying the biology of normal stem cells, stem cells in the development of disease, and mechanisms of tissue repair. The group aims to create a translational impact by attaining a deeper understanding of disease processes, developing novel therapies, and translating these to bedside

By understanding what controls liver regeneration in acute and chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of hepatic liver failure, liver cirrhosis and cancer. In particular, our main research interests are:

Biology of liver regeneration the hepatic progenitor cell niche

Biology of liver fibrosis and resolution

Cell therapy for liver regeneration

5 Publications

F.P.Russo, MR Alison, BW Bigger, E.Amofah, A.Florou, G. Bou-Gharios, JP Iredale, SJ Forbes. The bone marrow functionally contributes to liver fibrosis. Gastroenterology. 2006 May;130(6):1807-21

Burra P, Arcidiacono D, Bizzaro D, Chioato T, Di Liddo R, Banerjee A, Cappon A, Bo P, Conconi MT, Parnigotto PP, Mirandola S, Gringeri E, Carraro A, Cillo U, Russo FP. Systemic administration of a novel human umbilical cord mesenchymal stem cells population accelerates the resolution of acute liver injury. BMC Gastroenterol. 2012 Jul 12;12:88.

Tibaldi E, Zonta F, Bordin L, Magrin E, Gringeri E, Cillo U, Idotta G, Pagano MA, Brunati AM. The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling. Biochim Biophys Acta. 2014 Feb;1843(2):288-98.

Giobbe GG, Michielin F, Luni C, Giulitti S, Martewicz S, Dupont S, Floreani A, Elvassore N. Functional differentiation of human pluripotent stem cells on a chip. Nat Methods. 2015 Jul;12(7):637-40.

Secchi MF, Crescenzi M, Masola V, Russo FP*, Floreani A, Onisto M. Heparanase and macrophage interplay in the onset of liver fibrosis. Sci Rep. 2017 Nov 2;7(1):14956. doi: 10.1038/s41598-017-14946-0. *Corresponding author

Bizzaro D, Crescenzi M, Di Liddo R, Arcidiacono D, Cappon A, Bertalot T, Amodio V, Tasso A, Stefani A, Bertazzo V, Germani G, Frasson C, Basso G, Parnigotto P, Alison MR, Burra P, Conconi MT, Russo FP. Sex-dependent differences in inflammatory responses during liver regeneration in a murine model of acute liver injury. Clin Sci (Lond). 2018 Jan 25;132(2):255-272.

Funding 

Department funding

People involved:

Francesco Paolo Russo (Associate Professor)
Patrizia Burra (Full Professors)
Annarosa Floreani (Associate Professors)
Fabio Farinati (Full Professor)
Umberto Cillo (Full Professor)
Enrico Gringeri (Associate Professor)
Marina Bortolami (Assistant Professor, scientist)

Group members:

Debora Bizzaro and Francesca Secchi (post-doc)
Marika Crescenzi (PhD, specialist in clinical pathology, biologist)
Laura Borsetto, Romilda Cardin, Chiara Carlotto and Milena Minotto (biologists/laboratory technicians)