Human tumor immunology

The research activities of Mandruzzato laboratory are focused on the study of myeloid cells in the regulation of the anti-tumor immune response in cancer patients according to these lines of research:
Role of circulating and tumor-associated myeloid-derived suppressor cells (MDSC) in the immune evasion in cancer patients
Determination and harmonization of the subsets of human MDSC by multicolour flow cytometry
Immunotherapy with checkpoint inhibitors: role of MDSC as biomarkers of  response to these antibodies
Evaluation of new nanocapsule formulations as carrier of drugs targeting myeloid suppressive cells
Study of the innate immune response in glioma patients: evaluation of the function of tumor-associated myeloid cells in the tumor microenvironment

5 publications:

Mandruzzato S., Brasseur F., Andry G., Boon T. and van der Bruggen P.  A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.  Journal of Experimental Medicine, 186 : 785-793, 1997

Mandruzzato, S. Solito, S., Falisi, E., Francescato, S., Chiarion-Sileni, V., Mocellin, S., Zanon, A., Rossi, C. R., Nitti. D., Bronte, A. Zanovello, P. IL4Ra+ myeloid-derived suppressor cell expansion in cancer patients. Journal of Immunology 2009; 182 : 6562-6568.

Marigo, I., Bosio, E., Solito, S., Mesa-Pardillo, C., Gomez Fernandez, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., Calabresi, F., Zanovello, P., Basso, G., Cozzi, E., Mandruzzato, S., Bronte, V. Tumor-Induced +Tolerance and Immune Suppression Depend on the C/EBPbeta Transcription Factor. Immunity, 2010; 32(6):790-802.

Solito, S., Falisi, E., Diaz-Montero, CM., Doni, A., Pinton, L., Rosato, A., Francescato, S., Basso, G., Zanovello, P., Oniescu, G., Garrett-Mayer, E., Montero, AJ., Bronte, V., Mandruzzato, S. A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood, 2011;118(8):2254-65.

Mandruzzato, S. , Brandau S., Britten C.M., Bronte V., Damuzzo V., Gouttefangeas C., Maurer D., Ottensmeier C.H., Van der Burg S., Welters M.J.P., Walter S. Towards harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study. Cancer Immunology Immunotherapy. 2016 Feb;65(2):161-

funding :

AIRC Investigator Grant IG 2012. Project title: The dynamic interplay of MDSCs with T cells: envisioning new approaches for cancer immunotherapy. € 270.000 (2013-2015)

EURONANOMED II - Joint Transnational Call for Proposals (2013) Project title: Nano-Immuno-CHEmotherapy, Acronym: NICHE. € 197.000(2014-2016)

AIRC Investigator Grant IG 2016. Project title: “Unveiling the role of myeloid-derived suppressor cells in checkpoint blockade therapy”.   € 245.000 (2016-2018)

TRANSCAN-2: “Immunology and immunotherapy of cancer: strengthening the translational aspects”. Project title: Deciphering immune response against Glioblastoma to find new Targets. Acronym: Immunoglio.  € 300.000 (2017-2019)

people involved:

Susanna Mandruzzato, Associate Professor of Immunology

Group members:

PhD students: Marina Vettore, Sara Magri
Post Doc:
Laura Pinton
Elena Masetto, Ilaria Schibuola