Musculoskeletal pathology and oncology laboratory

Musculoskeletal Oncology
1.1.     Study of microenvironment in sarcoma tumours (chondrosarcoma, osteosarcoma and Ewing sarcoma);
1.2.     Exploring peritumoral tissues in patients with osteosarcoma and Ewing sarcoma treated with neoadjuvant chemotherapy
1.3.     Evaluation of biomarkers in sarcoma tumours and bone metastases
1.4.     In vitro study of new potential therapeutic molecules for sarcoma tumours treatment on cell lines and 3-D cultures

Physiopathology of musculoskeletal diseases and Regenerative Medicine
2.1.     Exploring the role of joint tissues (cartilage, meniscus, synovial membrane, infrapatellar fat pad, labrum, etc.) in osteoarthritis.
2.2.     Evaluation of therapeutic effects of different molecules (hyaluronic acid and its derivates, etc.) on primary cells isolated from osteoarthritic tissues.
2.3.     Evaluation of diseases biomarkers in osteoarthritis
2.4.     Isolation and characterization of stem cells from different joint tissues and evaluation of differentiation potential
2.5.     Study of metals release in patients with metal total hip arthroplasty


Belluzzi E, Olivotto E, Toso G, Cigolotti A, Pozzuoli A, Biz C, Trisolino G, Ruggieri P, Grigolo B, Ramonda R, Favero M. Conditioned media from human osteoarthritic synovium induces inflammation in a synoviocyte cell line. Connect Tissue Res. 2018 May 8:1-10. doi: 10.1080/03008207.2018.1470167.

Favero M, El-Hadi H, Belluzzi E, Granzotto M, Porzionato A, Sarasin G, Rambaldo A, Iacobellis C, Cigolotti A, Fontanella CG, Natali A, Ramonda R, Ruggieri P, De Caro R, Vettor R, Rossato M, Macchi V. Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study. Rheumatology (Oxford). 2017 Oct 1;56(10):1784-1793. doi: 10.1093/rheumatology/kex287.

Pinton L, Solito S, Damuzzo V, Francescato S, Pozzuoli A, Berizzi A, Mocellin S, Rossi CR, Bronte V, Mandruzzato S. Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression. Oncotarget. 2016 Jan 12;7(2):1168-84. doi: 10.18632/oncotarget.6662.

Iacobellis C, Berizzi A, Pozzuoli A, Biz C. Normalization of chromium and cobalt values after femoral head replacement. Int J Surg Case Rep. 2015;10:146-50. doi: 10.1016/j.ijscr.2015.03.037. Epub 2015 Mar 27.

People involved:

Ruggieri Pietro, MD, PhD - Full Professor

Group members:

Pozzuoli Assunta, Master of Science, Laboratory Manager
Belluzzi Elisa, PhD, Post-Doc